国际神经病学神经外科学杂志2012，Vol.39Issue(1)：16-19,4.
黄芩苷对海人酸致痫小鼠海马白细胞介素-1β及肿瘤坏死因子-α表达的影响
Effects of baicalin on the expression of IL-1 β and TNF-α in the hippocampus of kainate-induced epileptic mice
摘要
Abstract
Objective To study the effects of baicalin on the expression of interleukin-1β (IL-lβ) and tumor necrosis factor-a ( TNF-a) in the hippocampus of kainate-induced epileptic mice. Methods Fifty-four ICR male mice were randomly divided into three groups; control, status epilepticus (SE) and baicalin groups. To establish animal model of status epilepticus, 0. 1 μg/5 μi kainic acids was injected into the intracerebroventricular of the mice. HE staining was used to observe the pathological changes in hippocampus CA1 and CA3 areas. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot were used to detect the expression of the mRNA and protein levels of IL-1 β and TNF-α, respectively. Results Baicalin significantly relieved the hippocampal injury after SE in mice, and decreased the expression of IL-1α and TNF-a (P < 0.05 ). Conclusions Baicalin may derease the expression of IL-lα and TNF-a and thus provides a neuroprotective effect on the hippocampus after SE in mice.关键词
癫痫/黄芩苷/海人酸/白细胞介素-1β/肿瘤坏死因子-α/小鼠Key words
epilepsy/ baicalin/ kainic acid/ interleukin-1β/ tumor necrosis factor-a/ mice引用本文复制引用
欧阳龙强,梁日生,杨卫忠,石松生,王春华,涂献坤,王立胜..黄芩苷对海人酸致痫小鼠海马白细胞介素-1β及肿瘤坏死因子-α表达的影响[J].国际神经病学神经外科学杂志,2012,39(1):16-19,4.基金项目
福建省自然科学基金资助项目(2011J01175) （2011J01175）
