国际神经病学神经外科学杂志2012，Vol.39Issue(1)：20-24,5.
弥散张量成像在继发全面性发作癫痫患者中的应用研究
Diffusion tensor imaging in patients with secondary generalized epilepsy
宁红辉 1肖波 1刘楚娟 2黎思茹 1王美萍 1易芳 1卢晓琴 1胡崇宇 3解媛媛1
作者信息
- 1. 中南大学湘雅医院神经内科,湖南省长沙市410008
- 2. 湖南省马王堆医院康复科,湖南省长沙市410016
- 3. 湖南省人民医院神经内科,湖南省长沙市410005
- 折叠
摘要
Abstract
Objective To assess the role of diffusion tensor imaging ( DTI) in detecting seizure foci which can not be seen in conventional MRI in patients with secondary generalized epilepsy. Methods The diffusion weighted imaging results were obtained in 30 adult patients with secondary generalized seizures and 30 healthy controls using Siemens 3.0T MRI system. The data from patients and controls were analyzed on basis of voxel-based analysis. Results Fractional anisotropy (FA) of the patients decreased significantly compared with the controls (P <0.001) in the right uniform gyms and precuneus, right medial frontal gyms and uncus, left cingulate gyms , inferior temporal gyms, cerebellar tonsils, and left precentral gyms. Apparent diffusion coefficient (ADC) of the patients was significantly higher than the controls in the right parahippocampal gyms, inferior temporal gyms, corpus callosum, the right medial frontal gyms, inferior frontal gyros, cingulate gyms, anterior cingulate gyms, lingual gyms, fusiform gyms and occipital gyms, left middle temporal gyrus, uncus and left precentral gyms (P<0.001). However, ADC in the left gyms rectus of the patients decreased significantly compared with the controls. Conclusions Extensive white matter microstmcture abnormalities which cannot be seen on conventional MRI can be in patients with secondary generalized seizures by DTZ.关键词
癫痫/弥散张量/各项异性/磁共振成像Key words
epilepsy/ diffusion tensor imaging/ diffusion anisotropy/ magnetic resonance imaging引用本文复制引用
宁红辉,肖波,刘楚娟,黎思茹,王美萍,易芳,卢晓琴,胡崇宇,解媛媛..弥散张量成像在继发全面性发作癫痫患者中的应用研究[J].国际神经病学神经外科学杂志,2012,39(1):20-24,5.
