国际病理科学与临床杂志2012，Vol.32Issue(1)：45-49,5.
过氧化物酶体增殖物激活受体γ辅激活因子1α的研究进展
Research progress in peroxisome proliferator-activated receptor γ coactivator-1α
摘要
Abstract
In eukaryotes,cellular and systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor γ coactivator la (PGC-lα) is an important regulator of mitochondrial biogenesis and function. There is currently much interest in PGC-la, focusing on two important characteristics: tissue-specific expression and induction of a specific signal. PGC-la is expressed at high levels in tissues where mitochondria are abundant and oxidative metabolism is active. The signal induction activity of PGC-la is clearly related to the cell's energy metabolism state. For example, cold, fasting and exercise all contribute to a increase in PGC-la expression.关键词
过氧化物酶体增殖物激活受体γ辅激活因子1α/寒冷/禁食/运动Key words
peroxisome proliferator-activated receptor γ coactivator lα/ cold/ fasting/ exercise引用本文复制引用
王喜..过氧化物酶体增殖物激活受体γ辅激活因子1α的研究进展[J].国际病理科学与临床杂志,2012,32(1):45-49,5.基金项目
国家自然科学基金(C140406) （C140406）
