国际病理科学与临床杂志2012，Vol.32Issue(1)：50-54,5.
程序性坏死研究进展
Research progress in necroptosis
摘要
Abstract
Necroptosis is a novel programmed cell death mechanism which is caspase independent. It is mediated by specific signaling via a death receptor ligation. Necroptosis usually arises when the apoptotic pathway is inhibited, and is characterized by a necrotic morphology. Recently, many reports have revealed that necroptosis is precisely regulated by a cellular signaling pathway, like apoptosis.receptor interaction protein kinase 1 and receptor interaction protein kinase 3 kinases are the key regulators of this alternative cell death mechanism. Necroptosis contributes to the pathogenesis of numerous conditions, including inflammation, ischemic injury and neurodegeneration.Moreover,it has important significance in cancer drug resistance.关键词
程序性坏死/受体相互作用蛋白激酶1/受体相互作用蛋白激酶3/肿瘤耐药性Key words
necroptosis/ receptor interaction protein kinase 1/ receptor interaction protein kinase 3/ cancer drug resistance引用本文复制引用
伏媛..程序性坏死研究进展[J].国际病理科学与临床杂志,2012,32(1):50-54,5.基金项目
国家自然科学基金(81170486) （81170486）
江苏省国际科技合作计划(BZ2010041). （BZ2010041）
