神经损伤与功能重建2012，Vol.7Issue(2)：96-100,5.DOI:10.3870/sjsscj.2012.02.005
腺苷A2A受体阻断剂对戊四氮全面性癫痫发作模型及点燃模型的抑制作用
Inhibiting Effects of Adenosine A2A Receptor Antagonist on Generalised Convulsive Seizures Induced by Pentylenetetrazol and Pentylenetetrazol-induced Kindling on Rats
李巷 1康慧聪 1刘晓艳 1刘志广 1刘建林 1曾铮 1朱遂强1
作者信息
- 1. 华中科技大学同济医学院附属同济医院神经内科,武汉430030
- 折叠
摘要
Abstract
Objective: To investigate the effects of adenosine A2a receptor antagonist SCH58261 on generalised convulsive seizures induced by pentylenetetrazol and pentylenetetrazol-induced kindling. Methods: Generalised convulsive seizures and kindling models were induced in rats by intraperitoneal injection of pentylenetetrazol. Adenosine A2A receptor antagonist SCH58261 was given to rats and the treatment effect of SCH58261 was studied on the two epilepsy models. Results: Long-term administration of SCH58261 increased the latency of pentylenetetrazol induced clonic seizures but not inhibited the tonic seizures. Long-term administration of SCH58261 prevented the process of kindling and decreased severity of seizures on pentylenetet-razol-induced kindling model. Conclusion; Adenosine A2A receptor antagonist SCH58261 inhibits generalised convulsive seizures induced by pentylenetetrazol and pentylenetetrazol-induced kindling on rats.关键词
腺苷A2A受体阻断剂/戊四氮/癫痫模型Key words
adenosine A2A receptor antagonist/ pentylenetetrazol/ epilepsy model分类
医药卫生引用本文复制引用
李巷,康慧聪,刘晓艳,刘志广,刘建林,曾铮,朱遂强..腺苷A2A受体阻断剂对戊四氮全面性癫痫发作模型及点燃模型的抑制作用[J].神经损伤与功能重建,2012,7(2):96-100,5.
