神经损伤与功能重建2012，Vol.7Issue(2)：119-123,5.DOI:10.3870/sjsscj.2012.02.011
超声造影评价阿托伐他汀对颈动脉斑块内新生血管的影响
The Effect of Atorvastatin on Neovascularization in Carotid Atherosclerotic Plaques Evaluated by Contrast-Enhanced Uitrasonography
易黎 1冯淼玲 1钟洁愉2
作者信息
- 1. 北京大学深圳医院 神经内科,广东深圳518036
- 2. 汕头大学医学院,广东汕头515041
- 折叠
摘要
Abstract
Objective: To evaluate the effect of atorvastatin on neovascularization in carotid atherosclerotic plaques by contrast-enhanced ultrasonography (CEUS). Methods: Fifty-four patients who met the inclusive criteria were recruited for this study. In addition to the treatment of primary diseases, atorvastatin (20 mg/d) was given to all the patients for continuous 3 months. The plasma lipid levels, routine ultrasound examination and CEUS of the carotid plaques were taken and compared before and after the treatment. The primary end points and adverse reactions ' were setted up and documented. Results; Twenty-five patients (40 plaques) completed the stud-y. After the treatment, the plasma levels of low-density lipoprotein cholesterol (LDLC), tri-glyceride (TG), total cholesterol (TO and the regional blood volume (RBV), regional blood flow (RBF)were significantly decreased (P<0. Of). There were no significant changes in the in-tima media thick (IMT) , the thickeness and area of carotid plaques. No primary end points and adverse reactions -were recorded. Conclusion; Oral atorvastatin lessens the neovascularization in the carotid atherosclerotic plaques. CEUS is reliable to quantitatively evaluate the neovascularization in the carotid atherosclerotic plaques.关键词
超声造影/颈动脉/不稳定斑块/斑块新生血管/阿托伐他汀Key words
ultrasonography/ carotid arteries/ unstable plaque/ neovascularization/ atorvastatin分类
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易黎,冯淼玲,钟洁愉..超声造影评价阿托伐他汀对颈动脉斑块内新生血管的影响[J].神经损伤与功能重建,2012,7(2):119-123,5.
