神经损伤与功能重建2012，Vol.7Issue(2)：124-128,5.DOI:10.3870/sjsscj.2012.02.012
弥散张量成像对弥漫性轴索损伤的定量研究
A Quantitative Study of Diffuse Axonal Injury Using Diffusion Tensor Imaging
摘要
Abstract
Objective: To investigate the value of fractional anisotropy (FA) of diffusion tensor imaging (DTI) in severity assessment and prognosis prediction of diffuse axonal injury (DAI). Methods: Twenty-eight patients with DAI (DAI group) and 10 healthy control volunteers (control group) were recruited for the study. Glasgow coma scale (GCS) was used to assess the consciousness of DAI patients at admission. Patients received MR inspection within two weeks after onset and the data of DTI were collected. Glasgow outcome score (GOS) was used to evaluate the patients 6 months later. The fractional anisotropy (FA) values in different regions of interest (ROD were measured and compared. The correlation between FA values in different ROIs and GCS, GOS scores were analyzed. Results: When compared with the control group, the FA value was significantly decreased in each ROI of DAI group (P<0. 01). In DAI group, FA values were significantly lower in the visualized lesions than in the homologous ones in contralat-eral hemisphere (P<0. 01). The FA values in the brainstem (midbrain, pons and medulla oblon-gata) were positively correlated with GCS and GOS scores (P<0. 01). The FA values in the corpus callosum were positively correlated with GCS scores (P<0. 01). Conclusion; DTI is a potentially useful imaging modality to detect DAI lesions. Changes of FA value in ROIs help to assess the severity and the outcome of DAI.关键词
弥漫性轴索损伤/磁共振成像/弥散张量成像/各向异性分数Key words
diffuse axonal injury/ magnetic resonance imaging/ diffusion tensor imaging/ fractional anisotro"py分类
医药卫生引用本文复制引用
庄步峰,王洪财,段志新,吴芳芳,朱坤灿,张红,马延斌..弥散张量成像对弥漫性轴索损伤的定量研究[J].神经损伤与功能重建,2012,7(2):124-128,5.基金项目
上海交通大学"医工(理)交叉研究基金"项目(No.YG2009MS14) （理）
上海市卫生局科研基金(No.2008115) （No.2008115）
