神经损伤与功能重建2012，Vol.7Issue(3)：157-161,232,6.DOI:10.3870/sjsscj.2012.03.001
C型Niemann-Pick病小鼠小脑Purkinje细胞的电生理特性研究
Electrophysiological Characteristics of Purkinje Cells in Mouse Cerebellum of Niemann-Pick C Type Di-sease
摘要
Abstract
Objective: lo investigate the electrophysiological properties and calcium currents of Purkinje cells in mouse cerebellum of NPC and wild type mice. Methods: Fresh cerebel-lar slices were prepared and whole-cell patch clamp was applied to record the electrophysiological properties of Purkinje cells. The I-V curve of calcium channels and calcium current densities at different time points were establised. Results: No significant differences were found in the electrophysiological characteristics and calcium currents of Purkinje cells between NPC and wild type mice. Conclusion: In NPC mouse model, pathological cholesterol metabolism fails to modify the electrophysiological characteristics of Purkinje cells. It is reasonable to speculate that electrophysiological properties and calcium currents of Purkinje cells don't play an important role in NPC pathology.关键词
C型Niemann-Pick病/Purkinje细胞/细胞膜电生理/钙电流Key words
Niemann-Pick C type disease/ Purkinje cell/ electrophysiological properties/ calcium currents分类
医药卫生引用本文复制引用
曾莉,余姗姗,卜碧涛..C型Niemann-Pick病小鼠小脑Purkinje细胞的电生理特性研究[J].神经损伤与功能重建,2012,7(3):157-161,232,6.基金项目
国家自然科学基金(No.30670735) （No.30670735）
