神经损伤与功能重建2012，Vol.7Issue(3)：170-174,5.DOI:10.3870/sjsscj.2012.03.004
心型脂肪酸结合蛋白在急性缺血性脑卒中的早期诊断价值
Diagnostic Value of Heart-type Fatty Acid-Binding Protein in Acute Ischemic Stroke
摘要
Abstract
Objective: To explore the diagnostic value of heart-type fatty acid-binding protein (H-FABP) in acute ischemic stroke (AIS). Methods: DWI and MRI were acted as the gold standard, 146 cases were divided into AIS group (96 cases) and suspected Stroke group (50 cases). Eighty healthy cases were recruited as control group at the same time. The AIS group was further divided into large infarct, medium infarct and small infarct subgroups on the basis of infarction volume. The AIS group was further divided into cortex infarction, sub-cortical infarction and the cerebellum plus brain stem subgroups according to infarction sites. All demography and associated risk factors were collected. The levels of serum H-FABP were measured by ELISA in all the cases. Results: The levels of serum H-FABP in AIS group[ (1. 02 + 1. 33) ng/mL] were significantly higher than that in suspected Stroke group[(0. 18 + 0. 14)ng/mL] and control group [ (0. 13 + 0. 10) ng/mL] (P<0. 05). The levels of serum H-FABP showed difference in different infarct volume subgroups (P<C0. 05). The levels of H-FABP in serum presented no difference a-mong sites of infarction. The area under curve (AUCs) was 0. 897, and the diagnosis consistent rate was 82. 5%. Conclusion: H-FABP may be a sensitive biological marker in the early period of AIS. Serum H-FABP level is dependent on infarction lesion sizes but not the location.关键词
心型脂肪酸结合蛋白/急性缺血性卒中/生物学标志物/诊断/受试者工作特征曲线Key words
heart type fatty acid-binding protein/ acute ischemic stroke/ biological marker/ diagnosis/ receiver operating characteristics curves分类
医药卫生引用本文复制引用
张绿明,魏衡,李继来,赵静,杨旭,杜继臣..心型脂肪酸结合蛋白在急性缺血性脑卒中的早期诊断价值[J].神经损伤与功能重建,2012,7(3):170-174,5.基金项目
首都医学发展科研基金项目(No.2007-3115) （No.2007-3115）
