神经损伤与功能重建2012，Vol.7Issue(3)：193-194,228,3.DOI:10.3870/sjsscj.2012.03.010
绝经期女性脑梗死患者血清雌二醇及同型半胱氨酸的相关性分析
Correlation Analysis of Serum Estradiol and Homocysteine of Postmenopausal Women with Cerebral Infarction
潘宋斌 1万琳 2邵卫 1笱玉兰1
作者信息
- 1. 武汉市第一医院神经内科,武汉430022
- 2. 武汉市中医院内分泌科,武汉430014
- 折叠
摘要
Abstract
Objective: To investigate the changes of serum estradiol ( E2 ) and homocys-teine ( Hey ) in post-menopausal women with cerebral infarction, and to explore the correlation of E2 and Hey and their effect on outcome of patients with ischemic cerebral-vascular disease. Methods: Two hundred and fifty-four female patients were divided into menopause cerebral infarction group, menopausal non-cerebral infarction, non-menopausal cerebral infarction and non-menopausal non-cerebral infarction groups. The venous blood samples were obtained from patients and the E2 and homocysteine (Hey) levels in the serum were determined. Results:The Serum estradiol levels in menopausal cerebral infarction group were significantly decreased compared with those in the other three groups (P<C0. 05). The Serum estradiol levels in the non menopausal cerebral infarction group were significantly lower than those in the non menopausal non cerebral infarction group (P<C0. 05). The serum Hcy levels in cases in the menopausal cerebral infarction group were significantly increased relative to those in the other three groups (P<C0. 05). The Hcy levels in the non menopausal cerebral infarction group was significantly higher than that in the non menopausal non cerebral infarction group (P<C0. 05). The Serum estradiol levels were correlated negatively with homocysteine level in the postmenopausal women with cerebral infarction. Conclusion:Reduced estradiol levels correlate with elevated blood homocysteine levels,which may be involved in the pathological process of postmenopausal women with cerebral infarction.关键词
绝经脑梗死/雌二醇/同型半胱氨酸Key words
postmenopausal cerebral infarction/ estradiol/ homocysteine分类
医药卫生引用本文复制引用
潘宋斌,万琳,邵卫,笱玉兰..绝经期女性脑梗死患者血清雌二醇及同型半胱氨酸的相关性分析[J].神经损伤与功能重建,2012,7(3):193-194,228,3.
