广西医科大学学报2012，Vol.29Issue(2)：179-182,4.
马尾松树皮提取物抗肿瘤作用的实验研究
THE ANTITUMOR ROLE OF PINUS MASSONIANA BARK EXTRACT
摘要
Abstract
Objective: To investigate the antitumor activity of Pinus massoniana bark extract (PMBE) in S180 ascites tumor-bearing mice. Methods: After the intraperitoneal injection of PMBE in the S180 ascities tumor-bearing NIH mice, the changes of the body weight, ascites tumor size, tumor inhibition rate, thymus index, spleen index, peripheral leucocyte count and T lymphocyte proliferation rate, apoptosis rate and cell cycle were observed. Results: PMBE showed significantly inhibition on the growth of S180 ascites tumor cells. The inhibitory rates of PMBE were 9. 95%, 65. 74% and 88. 04% at the dosages of 50, 100, 200 mg/kg, respectively; a corresponding decline in weight gain of the mice. The dose of 200 mg/kg PMBE could increase the thymus index, spleen index, peripheral leucocyte count and T lymphocyte proliferation rate. The dose of 100 mg/kg PMBE could induce significantly S180 cell apoptosis, and the cell cycle analysis showed that PMBE induces cell cycle arrest in the S phase. Conclusion: PMBE could inhibit the growth of S180 ascites tumor by increasing immune function and inducing cell apoptosis.关键词
PMBE/S180/免疫功能/凋亡Key words
PMBE/S180/immune function/apoptosis分类
医药卫生引用本文复制引用
张锦宏,冯冬茹,刘兵,戚康标,刘炎明,王宏斌,谢衡,李若达,王金发..马尾松树皮提取物抗肿瘤作用的实验研究[J].广西医科大学学报,2012,29(2):179-182,4.基金项目
广东省工业攻关项目(No.2004B10401033) （No.2004B10401033）
广州医学院科研基金(No.04-K-19,0115-038111)资助 （No.04-K-19,0115-038111）
