广西医科大学学报2012，Vol.29Issue(2)：189-192,4.
血管周围脂肪组织在肾性高血压血管重构中的作用
EFFECTS OF PERIVASCULAR ADIPOSE TISSUE ON VASCULAR REMOLDING IN RENAL HYPERTENSION
史吉莹 1刘唐威 1黄荣杰 1林葆菁 1莫剑梅 1蒋智渊1
作者信息
- 1. 广西医科大学第一附属医院高血压病区,南宁,530021
- 折叠
摘要
Abstract
Objective: To investigate the effects and mechanisms of perivascular adipose tissue (PVAT) on vascular remolding in renal hypertension. Methods: Renal hypertension rat model was constructed through two kidney one clip (2k1c) technique. Thirty SD rats were randomly divided into sham (SH) and renal hypertension groups (RH, n = 15 for each). All rats were evaluated caudal blood pressure, heart rate (HR) after 12 weeks. The level of angiotensin (Ang) TJ was measured by radioimmunoassay. The expression of AGT and ACE was tested by Real-time quantitative PCR. Protein expression of AT1 and AT2 was detected using western blot. H2O2 was also detected in PVAT. Results: Twelve weeks after operation, the aortic remolding was discovered in RH group. The level of Ang TJ and the expression of AGT, ACE, AT1 and H2O2 were higher in RH group than in SH group. But the protein expression of AT2 was equal bet-ween the two groups. Conclusion: PVAT is related with vascular remolding in renal hypertension. ROS may be one of the factors in the mechanism of vascular remolding induced by PVAT.关键词
血管周围脂肪组织/血管紧张素Ⅱ/过氧化氢Key words
perivascular adipose tissue/angiotensin Ⅱ/H2O2分类
医药卫生引用本文复制引用
史吉莹,刘唐威,黄荣杰,林葆菁,莫剑梅,蒋智渊..血管周围脂肪组织在肾性高血压血管重构中的作用[J].广西医科大学学报,2012,29(2):189-192,4.
