郑州大学学报（医学版）2012，Vol.47Issue(3)：358-361,4.DOI:10.3969/j.issn.1671-6825.2012.03.026
大剂量甲强龙对兔髋关节周围骨组织BMP-2表达的影响
Effects of high dose methylprednisolone on expression of BMP-2 in bone around hip of rabbits
张永乐 1王义生 2张世清 1王晓1
作者信息
- 1. 河南大学淮河医院骨科,开封,475000
- 2. 郑州大学第一附属医院骨科,郑州,450052
- 折叠
摘要
Abstract
Aim:To study the effects of high dose methylprednisolone on expression of BMP-2 in acetabulum, caput ossis femoris and proximal femurs bone of rabbit.Methods:A total of 27 adult rabbits were randomly allocated into three groups,9 in each group.The rabbits in group A and group B were injected with methylprednisolone sodium succinate at 80 mg/(kg·d) for 3 and 6 days,respectively. The rabbits in group C were injected with normal saline. At 2,4,and 8 weeks after steroid administration, the bone tissue of acetabulum, caput ossis femoris and proximal femurs were collected to observe histopathological changes,and examine the expression of BMP-2 by immunohistochemical method.Results:The number of bone empty lacunae in caput ossis femoris and proximal femurs in group A and B were more than that of group C(Fgroup=116.782 and 110.112,Ftime=57.207 and 61.092,P<0.001),especially in group B(P<0.05).The average optical density of BMP-2 in acetabulum,caput ossis femoris and proximal femurs of group A and B were higher than those of group C(Fgroup=232.623,239.894,and 338.533;Ftime=273.064,198.320,and 230.326;P<0.001),especially in group B(P<0.05).Conclusion:High dose methylprednisolone can reduce the expression of BMP-2 in bone around hip.关键词
激素性股骨头坏死/骨形态发生蛋白-2/兔Key words
osteonecrosis of the femoral head/ BMP-2/rabbit分类
医药卫生引用本文复制引用
张永乐,王义生,张世清,王晓..大剂量甲强龙对兔髋关节周围骨组织BMP-2表达的影响[J].郑州大学学报（医学版）,2012,47(3):358-361,4.
