中医学报2012，Vol.27Issue(4)：438-440,3.
归脾汤对失眠小鼠镇静催眠及记忆巩固性障碍的影响
Influence of Guipi Decoction on the Sedative - Hypnotic Effect and Memory Consolidation Obstacles of the Mice
摘要
Abstract
Objective:To study the effect of Guipi Decoction on the sedative - hypnotic and memory consolidation obstacles of mice. Methods: The mice were randomly divided into the control group, positive group, high dose group of Guipi Decoction, medial dose group of Guipi Decoction and low - dose group of Guipi Decoction. The positive group was given diazepam 5 mg·( kg · D)-1 and Anshenbu-nao Syrup 800 mg · (kg · D)-1 for treatment. The high dose group was given 2000 mg · ( kg · D)-1 of Guipi Decoction; the medial dose group was given 1000 mg · (kg· d)-1 of Guipi Decoction;the low dose group was given 500 mg · (kg · D)-1 of Guipi Decoction. The number of activities and the standing number of the mice within 5 min were determined. The sleep latency, sleep duration and the content of mouse brain monoamine neurotransmitter of the mice in each group were recorded and determined. The mice were given subcutaneous injection of sodium nitrite ( NaNO2 120 m·g-1g ) to build mice models with memory consolidation obstacles. The time of the mice jumping off the platform (ie, electric shock latency) and the number of jumping withinlO min(ie,the number of errors) were recorded as the memory index. Results:The number of activities and standing up of the mice decreased(P <0. 05). It could extend the mouse's sleeping - time caused by napental(P <0.05 or 0.01). It also could significantly increase 5 - HT,DA,NA and 5 - HIAA levels in the brain tissue of the mice( P < 0. 05 or 0.01) . Beside, it also could extend a certain incubation period of electric shock,and reduce the number of errors of the mice within 10 min(P < 0. 05 ) . Conclusion: Guipi Decoction has obviously sedative - hypnotic effect and the function of improving the learning abilities and memory.关键词
归脾汤/失眠/镇静催眠/记忆巩固性障碍/安定片/安神补脑液/小鼠Key words
guipi decoction/insomnia/sedative and hypnotic/memory consolidation obstacles/diazepam/anshenbunao syrup/mice分类
医药卫生引用本文复制引用
邓敏贞,黎同明..归脾汤对失眠小鼠镇静催眠及记忆巩固性障碍的影响[J].中医学报,2012,27(4):438-440,3.基金项目
广东省自然科学基金项目(编号:K2100027) （编号:K2100027）
