中医学报2012，Vol.27Issue(6)：704-705,2.
石斛合剂对糖尿病模型大鼠胰岛细胞凋亡及诱导型一氧化氮合酶表达的影响
Enfluence of Shihu Mixture on Pancreatic Islet Cell Apoptosis and INOS Expression of Rat Models of Diabetes
高尤亮 1施红 2杨秀珍 3余文珍 2郑燕芳 2王晓宁2
作者信息
- 1. 福建省第二人民医院,福建福州350003
- 2. 福建中医药大学,福建福州350108
- 3. 泰州市人民医院,江苏泰州225300
- 折叠
摘要
Abstract
Objective: To investigate the influence of Shihu Mixture on pancreatic islet cell apoptosis and iNOS expression of rat models of high glucose and fat as well as STZ. Methods: Rats were given intraperitoneal injection of low doses of STZ ( 30 rag) after the feeding of high fat and sugar for the preparation of DM models to detect pancreatic islet cell apoptosis and the expression of iNOS, after treated with Shihu Mixture. Results: Shihu Mixture could significantly reduce blood glucose (P < 0.05) and significantly reduce the pancreatic islet cell apoptosis of DM rat models (P<0.05) and iNOS expressions( P <0.01). Conclusion:Shihu Mixture can reduce the blood glucose of DM rat models and reduce apoptosis of pancreatic islet cells, which may be related to the decrease of the synthesis of pancreatic NO of DM rat models.关键词
糖尿病/石斛合剂/细胞凋亡/诱导型一氧化氮合酶/基因实验研究/大鼠Key words
diabetes/shihu mixture/apoptosis/inducible nitric oxide synthase/gene experimental study/rat分类
医药卫生引用本文复制引用
高尤亮,施红,杨秀珍,余文珍,郑燕芳,王晓宁..石斛合剂对糖尿病模型大鼠胰岛细胞凋亡及诱导型一氧化氮合酶表达的影响[J].中医学报,2012,27(6):704-705,2.
