中医药导报2012，Vol.18Issue(6)：70-72,3.
丹紫康膝冲剂对兔膝骨性关节炎软骨水及血清碱性磷酸酶的影响
Study on the impact of Dan zi kang xi granules on the moisture of cartilage and alkaline phosphatase of serum of knee osteoarthritis of rabbits
摘要
Abstract
Objective: To explore the efficacy of Danzikangxi granules in the treatment of the knee osteoarthritis.Method: Rabbits were randomly divided into 6 groups,Other than the normal group, Danzikangxi granules high dose group、 medium dose group、low dose group(Short for Danzi high、medium、low dose group)、model control group and Zhuangguguanjiewan group(Short for Zhuanggu group) were, respectively, in 1、4、7 days a week injection of 0.5 mL 4% papain.And then rabbits were treated with drug or water.Observing the general condition of articular cartilage and detecting water ratio of articular cartilage and alkaline phosphatase of serum.Results: The difference in rate of moisture between model group and normal group was statistically significant (P<0.01).The differences in rate of moisture between Danzi high、medium、low dose group、Zhuanggu group and model group were statistically significant (P<0.01). The differences in the content of alkaline phosphatase between model group and normal group was statistically significant (P<0.01). The differences in the content of alkaline phosphatase between Danzi high、medium、low dose group 、Zhuanggu group and model group were statistically significant (P <0.01). Conclusion:Danzikangxi granules can adjust the content of moisture and alkaline phosphatase of serum of the knee osteoarthritis of rabbits ,and high、medium dose better than low dose.关键词
丹紫康膝冲剂/骨性关节炎/软骨/含水率Key words
Danzikangxi granules/ osteoarthritis/ cartilage/ water ratio分类
医药卫生引用本文复制引用
陆小龙,陈孟交,肖四旺,郑春成..丹紫康膝冲剂对兔膝骨性关节炎软骨水及血清碱性磷酸酶的影响[J].中医药导报,2012,18(6):70-72,3.基金项目
湖南省自然科学基金(09JJ6055) （09JJ6055）
