华西口腔医学杂志2012，Vol.30Issue(2)：209-213,5.DOI:10.3969/j.issn.1000-1182.2012.02.024
多孔纳米钙磷陶瓷支架材料生物相容性评价
Biocompatibility of porous calcium phosphate ceramic nanocomposite
摘要
Abstract
Objective To study the biocompatibility of porous calcium phosphate ceramics nanocomposite. Methods The biocompatibility was evaluated via experiments including the hemolysis test, hemopexis test, acute systemic toxicity test, pyrogen test, and intramuscular implant test, in which biphasic calcium phosphate nanocomposite (NanoBCP) presented as leaching solution, suspension or blocks of 5 mmx5 mmxl mm. Animals including New Zealand Rabbits, Kunming mice, SD rats were selected as the host. Results The hemolysis of NanoBCP was 1.1% (<5%). Four coagulation index levels were within the normal range. In pyrogen test, the temperature of each experimental rat increased by 0.35, 0.40, 0.28 °C (<0.60°C, in accordance with the pyrogen-free criterion for biomedical materials). No consequent death, dyspnoea, organ dysfunction, severe peritoneal irritation or ptosis was observed in acute systemic toxic test. Newly-formed fibrous tissue could be found after the implantation. Conclusion The material possesses outstanding biocompatibility and degradability with no toxicity or irritation, contains no pyrogen, as well as better degradation properties than biphasic calcium phosphate.关键词
纳米材料/支架材料/磷酸钙陶瓷/生物相容性Key words
nanocomposite/scaffolds/calcium phosphate ceramics/biocompatibility分类
医药卫生引用本文复制引用
张可夫,张舒,罗志强,王璟,王涛,欧国敏,王虎..多孔纳米钙磷陶瓷支架材料生物相容性评价[J].华西口腔医学杂志,2012,30(2):209-213,5.基金项目
国家自然科学基金资助项目(81070868,10675087) （81070868,10675087）
