董喆 1徐雅萍 2龚美亮 2丁志平 1闫中强 1陈黎明3
作者信息
- 1. 100853 北京 解放军总医院南楼临床部感染管理科
- 2. 100853 北京 解放军总医院南楼临床部检验科
- 3. 100853 北京 解放军总医院南楼临床部医务部
- 折叠
摘要
Abstract
Objective To investigate the status of multidrug-resistant genes carried by Acinetobacter baumannii isolates from elderly patients in our hospital in order to provide a basis for surveillance of drug-resistance and inflection control. Methods One hundred and twenty A. Baumannii isolates were collected from elderly patients between 2008 and 2010. The mean age of the patients was 85 (65 to 95) years. Whonet 5.6 software was used to analyze the susceptibility of 16 antimicrobial agents. Polymerase chain reaction (PCR) and the sequencing method were adopted to detect 10 kinds of resistance genes (blaOXA-51-like blaOXA-23-like, blaOXA.24.like, blaOXA-58-like,blaTEM,blaampC, armA, ISAfcal, intl 1, and intl 2). The corresponding resistance gene profiling(RGP) was analyzed and designated according to the status of resistance genes. Results The rates of resistance to the remaining 15 kinds of antibiotics varied between 70.8% and 97.5%, with the exception of the sensitive rate to polymyxin B by up to more than 90%. The positive rates of blaOXA-51-like、 blaQXA-23-like、bla0XA-58-like、blaTEM、blaampc、 armA、 ISAbal and intl I were 100%, 81.7%, 0.8%, 10.8%, 91.7%, 81.7%, 86.7%, and 83.3% respectively. A total of 18 kinds of drug-resistant gene maps were found, but W"oxa-24-like. And intI 2 were not detected. Among these gene maps, the rate of RGP1 (blaOXA23_[lkc+blaalipC+armA+lSAbal + intl 1) was as high as 60.8%. Conclusions A. Baumannii isolates from elderly patients have a higher carrying rate of drug-resistant genes, resulting in serious multidrug-resistant conditions. Therefore, full-time infection control personnel and clinical physicians should actively participate in the surveillance, prevention, and control of infections caused by A. Baumannii in the elderly.关键词
老年人/鲍氏不动杆菌/抗药性,多种细菌/交叉感染Key words
aged/ Acinetobacter baumannii/ drug resistance, multiple, bacterial/ cross infection分类
医药卫生
