解放军医学杂志2012，Vol.37Issue(4)：360-363,4.
术前应用石杉碱甲对老年患者术后认知功能的影响
Effects of preoperative application of huperzine A on postoperative cognitive function in elderly patients
摘要
Abstract
Objective To observe the influence of huperzine A on postoperative cognitive function in elderly patients. Methods Eighty patients, aged 65 to 75, American Society of Anesthesiologists (ASA) grade I to E , undergoing laparoscopic cholecystectomy, were randomly divided into experimental group and control group. Forty cases were assigned to each group. The experimental group and the control group were intravenously injected with 0.2mg each of huperzine A or normal saline everyday for 3d before operation. The awakening time of the patient after operation was recorded. Mini mental state examination (MMSE) was used to assess the cognitive function of the patients before the operation and 3h, 6h, 24h, 3d, and 1 week after the operation. In addition, protein S100 (3 levels in the serum before operation and 3h, 6h, 24h, 3d, and 1 week after the operation were determined. Results The MMSE scores of both groups were lower after operation than that of preoperative in different degrees. The awakening time of experimental group (23 ± 3min) was shorter than that of the control group (31 ± 5min, P<0.05). The MMSE scores at 3h, 6h, 24h, and 3d after operation were 19.2 ± 1.4, 20.3 ± 1.5, 22.4 ± 1.6, and 24.2 ± 1.6 respectively in the experimental group, and they were noticeably higher than those of the control group (16.5 ± 1.3, 17.3 ± 1.3, 18.8 ± 1.4, and 21.5 ± 1.4, respectively, P<0.05). The incidence of postoperative cognitive dysfunction (POCD) was lower in the experimental group than in the control group at 3, 6, and 24h after the operation (2, 4, and 2 and 9, 11, and 8 cases respectively, P<0.05). Postoperative delirium occurred in one patient in the experimental group, and it was lower than that in the control group (6 cases, P<0.05). S100 (3 protein values increased at 3 and 6h in both groups (P<0.01), while the values at 3, 6, and 24 h in the experimental group were lower than those in the control group (P<0.05). Conclusion Huperzine A injection could lower the incidence of PODC in elderly patients.关键词
石杉碱甲/术后认知功能障碍/老年人Key words
huperzine A/post-operative cognitive dysfunction/aged分类
医药卫生引用本文复制引用
吴安生,赵敏,易兴阳,占爱霞,张序忠,张绿秀,钱江洁..术前应用石杉碱甲对老年患者术后认知功能的影响[J].解放军医学杂志,2012,37(4):360-363,4.基金项目
温州市科技局科研基金(Y20100215) （Y20100215）
