江苏大学学报（医学版）2012，Vol.22Issue(3)：231-235,5.
利莫那班改构物对高脂饮食诱导肥胖小鼠的减肥效应及机制
Lose-weight effect to high fat diet-induced obese mice of an analogue of rimonabant
摘要
Abstract
Objective: A series of analogues of rimonabant were synthesized to investigate their lose-weight effect and mechanisms. Methods: The IC50 of analogues on the CB1 were determined by Radioactive-ligand receptor binding assay, male ICR mice were fed with high fat diet to build the obese mice model and treated with 10 mg/kg or 30 mg/kg ZH per day for 4 weeks. Body weight and the content/morphology of genital peripheral adipose tissue were detected, the content of total cholesterol (TC) and triacylglycerol (TG) in serum were also estimated. Results; ZH had the inhibition on the CB1, it could significantly reduce the food intake and body weight, the content of genital peripheral adipose tissue, TC and TG in serum were reduced. Conclusion; ZH could suppress the CB1, ZH reduced the weight through inhibiting appetite and blood lip-id levels.关键词
利莫那班改构物/减肥/高脂饮食/CB1受体Key words
analogue of rimonabant/ lose-weight/ high-fat diet/ CB1 receptor分类
医药卫生引用本文复制引用
杨海冬,高静,李静,范如霖,姚虎,冯建科..利莫那班改构物对高脂饮食诱导肥胖小鼠的减肥效应及机制[J].江苏大学学报（医学版）,2012,22(3):231-235,5.基金项目
镇江市新兴产业科技专项基金资助项目(CY2011026) （CY2011026）
