江苏大学学报（医学版）2012，Vol.22Issue(3)：242-246,5.
氟伐他汀对血管紧张素Ⅱ诱导的系膜细胞AT1受体和Ⅳ型胶原表达的影响
Effects of fluvastatin on the expression of angiotensin Ⅱ type 1 receptor and type Ⅳ collagen induced by angiotensin Ⅱ in mesangial cells
顾琳 1周艳芳 2王好 2张赢予 2张国辉2
作者信息
- 1. 江苏大学附属人民医院 肾内科,江苏镇江212002
- 2. 江苏大学附属人民医院 心内科,江苏镇江212002
- 折叠
摘要
Abstract
Objective: To investigate the expression of angiotensin Ⅱ type 1 receptor (AT1R) and type Ⅳ collagen (Col Ⅳ) induced by angiotensin Ⅱ (AngⅡ ) and the effects of fluvastatin on the expression of AT1R and Col Ⅳ in normal rat gloraerular mesangial cells(HBZY-1) , and to explore the possible mechanisms of fluvastatin renoprotection. Methods: HBZY-1 were divided into following groups according to different factors; Control group, Ang Ⅱ (different concentration 0. 1, 1.0, 10 μmol/L) group, 1.0μmol/L AngⅡ + fluvastatin(different concentration 0. 1,1.0,10 μmol/L) group. The expression of AT1R was measured using Western blot respectively and the secretion of Col Ⅳ protein was quantitated by ELISA. Results : The expression of AT1 R and Col Ⅳ were upregulated by Ang Ⅱ in a dose-dependent manner. Fluvastatin could inhabit the expression of AT1 R and Col Ⅳ induced by Ang Ⅱ in a dose-dependent manner. Conclusion: Fluvastatin could inhabit the expression of AT1R and Col Ⅳ induced by Ang Ⅱ. At the same time, the expression of AT1 R was positive correlation with Col Ⅳ, and has beer inferred, fluvastatin could improve hypertensive renal sclerosis by down-regulating AT1R and Col Ⅳ.关键词
氟伐他汀/血管紧张素Ⅱ/血管紧张素Ⅱ1型受体/Ⅳ型胶原/高血压肾脏硬化Key words
fluvastatin/ angiotensin Ⅱ / angiotensin Ⅱ type 1 receptor/ type Ⅳ collagen/ hypertensive renal sclerosis分类
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顾琳,周艳芳,王好,张赢予,张国辉..氟伐他汀对血管紧张素Ⅱ诱导的系膜细胞AT1受体和Ⅳ型胶原表达的影响[J].江苏大学学报（医学版）,2012,22(3):242-246,5.
