江苏大学学报（医学版）2012，Vol.22Issue(3)：262-264,3.
CYP11B2基因多态性与慢性心力衰竭及醛固酮水平的相关性研究
Relationship of CYP11B2 gene polymorphism with chronic heart failure and plasma aldosterone level
朱清艳 1顾水明2
作者信息
- 1. 江苏大学临床医学院,江苏镇江212001
- 2. 上海市徐汇区中心医院心内科,上海200031
- 折叠
摘要
Abstract
Objective: To study the relationship between CYP11B2 gene -344T/C polymorphism, chronic heart failure (CHF) and plasma aldosterone levels in CHF patients. Methods: CYP11B2 gene -344T/ C polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) in 256 subjects (96 patients with CHF and 160 controls), and the levels of plasma aldoslerone in patients with CHF was assessed by ELJSA. Results: No significant difference was found in genotype or al-lele frequency distribution between groups of control and CHF (χ2 =2. 50, P =0. 287; χ2 =2. 31, P = 0. 129). The levels of plasma aldosterone in patients with CHF was (181.49 ±46. 23)pg/ml in TT genotype class, (160.31 ±28.82)pg/ml in TC class and (148.02 ±24.39)pg/ml in CC class; TT vs. CC, t = 1.99, P=0.029; TT + CTt vs. CC, t = 1.71, P=0.043. Conclusion: There was no association between the -344T/C polymorphism of CYP11B2 gene and CHF. The -344T/C polymorphism of CYP11B2 gene was associated with plasma aldosterone levels in patients with CHF.关键词
慢性心力衰竭/醛固酮合酶(CYP11B2)基因多态性/醛固酮Key words
chronic heart failure/ CYP11B2 gene polymorphism/ aldosterone分类
医药卫生引用本文复制引用
朱清艳,顾水明..CYP11B2基因多态性与慢性心力衰竭及醛固酮水平的相关性研究[J].江苏大学学报（医学版）,2012,22(3):262-264,3.
