实用临床医药杂志2012，Vol.16Issue(5)：41-43,3.
不同浓度氧通气对先天性心脏病患儿体外循环肺功能的影响
Impact of ventilation with different concentrations of oxygen on lung functions after cardiopulmonary bypass in children with congenital heart disease
摘要
Abstract
Objective To observe the effects of ventilation with different concentrations of oxygen on lung functions after cardiopulmonary bypass(CPB) in congenital heart disease patients. Methods Thirty patients of elective surgery for noncyanotic congenital heart disease patients were randomly divided into two groups. Group H (n = 15) received 100% oxygen before and after CPB and group L (n = 15) received 50% oxygen at the corresponding time. Before CPB and 1 hour and 6 hours after CPB, blood sample were collected from the radial artery and pulmonary artery for gas analysis. A formula was used to calculate the oxygenation index (PaQ2/FiO2), respiratory index (RI) and pulmonary shunt ratio (Qs/Qt). Meanwhile, venous blood was taken to measure superox-ide dismutase (SOD) and malondialdehyde (MDA). Results One hour after CPB, PaQ2 and FiO2 of the two groups were lower than the levels before CPB. Six hours after CPB, PaO2/FiO2 were not different from the levels before CPB in group L, but remained significantly lower in group H. One hour after CPB, RI or Qs/Qt were higher than the levels before CPB in group H. The SOD activity decreased -and MDA production increased in both groups, while the group H showed more consumption of SOD and higher MDA content than group L one hour after CPB. Conclusion Lung ventilation with 50% oxygen in children with congenital heart disease during extracorporeal circulation surgery can reduce ischemia -reperfusion oxygen radical damage and help to improve lung oxygenation.关键词
先天性心脏病/体外循环/肺损伤/氧浓度Key words
congenital heart disease/ cardiopulmonary bypass/ lung injury/ oxygen concentration分类
医药卫生引用本文复制引用
陆志强,陈惠裕..不同浓度氧通气对先天性心脏病患儿体外循环肺功能的影响[J].实用临床医药杂志,2012,16(5):41-43,3.基金项目
南京医科大学科技发展基金资助项目(07NUMU041) （07NUMU041）
