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F344大鼠血液学指标正常参考值范围探讨

韩刚 原野 施畅 董延生 沈伽弟 李玉凤 王全军 王和枚 丁日高

军事医学2012,Vol.36Issue(5):354-356,3.
军事医学2012,Vol.36Issue(5):354-356,3.

F344大鼠血液学指标正常参考值范围探讨

An approach to reference values of hematology indexes in F344 rats

韩刚 1原野 1施畅 1董延生 1沈伽弟 1李玉凤 1王全军 1王和枚 1丁日高1

作者信息

  • 1. 军事医学科学院毒物药物研究所,国家北京药物安全评价中心,北京,100850
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摘要

Abstract

Objective To construct the reference values of hematology indexes in SPF F344 rats. Methods The hema-tology indexes in SPF F344 rats of both genders and different ages were measured by the hematology analyzer. The effect of gender and age of the rat on the indexes of hematology was analyzed and the reference values of the indexes of hematology with 95% confidence levels were constructed. Results Significant difference was found between male and female rats in RBC,RBC distribution width( RDW ), WBC, mean corpuscular hemoglobin( MCH ), MCH concentration MCHC ), RET# and RET% and between rats of different ages in NE% , LY% , RBC, HCT and Hb. Conclusion Statistically significant difference in some homological parameters is observed in F344 rats of different sexes and ages.

关键词

F344大鼠/血液学指标/参考值

Key words

F344 rat/hematology indexes/reference value

分类

医药卫生

引用本文复制引用

韩刚,原野,施畅,董延生,沈伽弟,李玉凤,王全军,王和枚,丁日高..F344大鼠血液学指标正常参考值范围探讨[J].军事医学,2012,36(5):354-356,3.

基金项目

国家科技重大专项资助项目(2008ZX09305-003,2010ZXJ0900X-005) (2008ZX09305-003,2010ZXJ0900X-005)

军事医学

OA北大核心CSCDCSTPCD

1674-9960

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