O6-(对-羧基苄基)鸟嘌呤的合成方法OA北大核心CSCDCSTPCD
Synthesis of oncotherapeutic sensitizer O6-(p-carboxylbenzyl) guanine
目的 合成作为肿瘤增敏剂和荧光探针分子连结子的新化合物O6-(对-羧基苄基)鸟嘌呤.方法 以2-氨基-6-氯嘌呤(ACP)为起始原料,与三乙烯二胺(DABCO)反应生成DABCO-嘌呤,再进行亲核取代反应得到O6-(对-氰基苄基)鸟嘌呤这一重要中间体,最后将氰基水解为羧酸制得O6-(对-羧基苄基)鸟嘌呤.结果与结论 合成获得了新结构化合物O6-(对-羧基苄基)鸟嘌呤,其结构经1H-NMR、LC-MS 、13C-NMR谱得到确证,总收率为61.4%…查看全部>>
Objective To synthesize an oncotherapeutic sensitizer and fluorescence molecule probe connector named O6-(p-carboxylbenzyl )guanine. Methods The target compound was synthesized from ACP with DABCO to obtain DABCO-purine, O6-( p-cyanobenzyl )guanine was obtained via nucleophilic substitution reaction,and then cyano was hydrolyzed into carboxyl group to get 0 -( p-carboxylbenzyl )guanine. Results and Conclusion A new-structure compound 0 -( js-carboxy-lbenzyl …查看全部>>
李露;张珩;杨艺虹;钟武
武汉工程大学,武汉,430073军事医学科学院毒物药物研究所,北京,100850武汉工程大学,武汉,430073武汉工程大学,武汉,430073
医药卫生
O6-(对-羧基苄基)鸟嘌呤化学合成抗肿瘤药
O6-(p-carboxylbenzyl)guaninechemical synthesis antineoplastic agents
《军事医学》 2012 (5)
372-375,4
国家科技支撑计划资助项目(2011BAI18B01)
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