摘要
Abstract
Objective To assess the clinicopathological features and their relations with the prognosis of idiopathic membranous nephropathy ( IMN ). Methods Fifty-two patients with IMN biopsied between 1991 and 2006, who were fol-lowed up for at least 52 months or till end-stage renal failure( double serum creatinine, death or dialysis ), were retrospec-tively analyzed. According to renal function, 52 patients were divided into stable renal function group and end stage renal disease group. The factors that influenced kidney prognosis were analyzed using Logistic regression analysis. Results Of the 52 IMN patients treated with corticosteroids and immunosuppressive drugs, 10 patients progressed to end stage renal disease, and 42 maintained renal function. There were significant differences in gender, mean arterial pressure ( MAP ), nephrotic syndrome, cholesterol, triglycerides ( TG ), glomerular filtration rate ( GFR ), tubulointerstitial fibrosis between these two groups. Logistic regression analysis showed that gender, 24 h urinary protein,GFR, tubulointerstitial fibrosis were related to renal progression. Conclusion Gender, 24 h urinary protein, GFR and tubulointerstitial fibrosis may be important factors that influence IMN outcome. In clinical practice, different treatment options should be chosen according to the exist-ing factors.关键词
肾小球肾炎,膜性/肾活检/肾小球滤过率/肾病综合征/预后Key words
glomerulonephritis membranous/ kidney biopsy/ glomerular filtration rate/ nephrotic syndrome/ prognosis分类
医药卫生
