军医进修学院学报2012，Vol.33Issue(3)：260-264,5.
胃壁注射A型肉毒毒素对大鼠摄食量、体重和脑肠肽ghrelin、NPY表达的影响
Effect of intragastric botulinum toxin A on food intake, body weight and expression of ghrelin and NPY in rats
摘要
Abstract
Objective To study the effect of intragastric botulinum toxin A(BTX-A) on food intake, body weight and expression of ghrelin and NPY in rats and its mechanism underlying anti-obesity. Methods Seventy-two rats were randomly divided into 2-week group, 6-week group, and 12-week group(24 in each group). The 24 rats in each group were further divided into control group, antrum BTX-A group, fundus BTX-A group, and multi-site BTX-A group(6 in each subgroup) to observe their food intake and body weight, plasma ghrelin and NPY levels, immunohistochemical change of ghrelin in stomach and NPY in hypothalamus, and expression of ghrelin-mRNA and NPY-mRNA in stomach and in hypothalamus. Results The food intake and body weight were less in different BTX-A groups than in control group(P<0.05). The expression levels of ghrelin and NPY in plasma and gastric tissue were lower in different BTX-A groups than in control group(P<0.05). However, they were higher in multi-site BTX-A group than in fundus BTX-A group and antrum BTX-A group(P<0.05). The difference gradually became less in the 4 groups 2, 6, and 12 weeks after intragastric BTX-A. Conclusion Intragastric BTX-A can decrease the food intake and body weight of rats by down-regulating the expression of brain-gut peptides, such as ghrelin and NPY, which may be one of the mechanisms of BTX-A underlying anti-obesity.关键词
A型肉毒毒素/肥胖/脑肠肽/胃促生长素/神经肽Key words
botulinum toxin A/ obesity/ brain gut petide/ ghrelin/ NPY分类
医药卫生引用本文复制引用
陈英,杨春敏,刘庆森,孟科..胃壁注射A型肉毒毒素对大鼠摄食量、体重和脑肠肽ghrelin、NPY表达的影响[J].军医进修学院学报,2012,33(3):260-264,5.基金项目
首都科学发展科研基金项目(2005-2043) （2005-2043）
