军医进修学院学报2012，Vol.33Issue(3)：277-279,301,4.
巴戟天对大鼠心肌缺血再灌注损伤的影响
Effect of Radix morindae offieinalis on myoeardial ischemia-reperfusion injury in rats
李凯 1司忠义 1李岩欣 1黄坤1
作者信息
- 1. 辽宁医学院附属第一医院心脏大血管外科,辽宁锦州121001
- 折叠
摘要
Abstract
Objective To study the possible mechanism of radix morindae offieinalis(RMO) underlying myocardial ischemia-reperfusion injury (IRI) in rats by observing its effect on IRI. Methods Forty male rats were randomly divided into sham operation group, myocardial IRI model group, high- and low- dose RMO groups(10 rats in each group). Rats in sham operation group and high- and low- dose RMO groups received a same volume of distilled water. Coronary artery in rats of sham operation group was not ligated, while the left anterior descending(LAD) of coronary artery in rats of the other 3 groups was ligated for 30min and reperfused for 60min. Then, their cardiac Infarction size, and creatine kinase (CK), Na+-K+-ATPase, Ca2+-Mg2+-ATPase, nitric oxide(NO) and iNOS levels in myocardial tissue were measured. Results The cardiac infarction size was significantly smaller while the Na+-K+-ATPase,Ca2+-Mg2+-ATPase, NO and iNOS levels in myocardial tissue were higher and the CK level was lower in IRI model group than in high- and low- dose RMO groups(P<0.05). Conclusion RMO can protect myocardium against IRI in rats by preventing calcium overload and reducing oxygen free radicals.关键词
巴戟天/缺血/再灌注/心肌预适应/ATP酶/一氧化氮Key words
radix morindae offieinalis/ myocardial ischemia/reperfusion/ ischemic preconditioning/ ATPase/ nitric oxide分类
医药卫生引用本文复制引用
李凯,司忠义,李岩欣,黄坤..巴戟天对大鼠心肌缺血再灌注损伤的影响[J].军医进修学院学报,2012,33(3):277-279,301,4.
