军医进修学院学报2012，Vol.33Issue(6)：562-564,3.
依托考昔治疗膝骨关节炎的短期疗效及安全性观察
Short-term therapeutic effect of etoricoxib on knee osteoarthritis and its safety
李林光 1朱剑 1张江林 1黄烽1
作者信息
- 1. 解放军总医院,风湿科,北京,100853
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect of etoricoxib on knee osteoarthritis(OA) and its safety. Methods Twenty-five patients with knee OA were treated with oral etoricoxib at the dose of 60mg/d. Its therapeutic effect and safety were assessed at weeks 0 and 3, such as Western Ontario McMaster Universities Osteoarthritis(WOMAC) index score (pain, stiffness, and daily activity difficulty), score of knee pain and disease given by patients, and score of disease given by physicians. The treatment was judged effectively when the improved index was ≥ 30%. Results All the indexes were significantly improved 3 weeks after treatment with etoricoxib(P<0.01). The therapeutic effect was ≥ 68% except for stiffness and 80% for knee pain. Adverse reaction, mainly manifested as gastrointestinal symptoms and edema, occurred in 5 patients(20%), which improved without reducing the dose or withdrawal of etoricoxib. No severe adverse events occurred. Conclusion Etoricoxib can improve the symptoms of knee OA with mild adverse reaction and good compliance.关键词
依托考昔/骨关节炎/疗效/安全性Key words
etoricoxib/ osteoarthritis/ efficacy/ safety分类
医药卫生引用本文复制引用
李林光,朱剑,张江林,黄烽..依托考昔治疗膝骨关节炎的短期疗效及安全性观察[J].军医进修学院学报,2012,33(6):562-564,3.
