军医进修学院学报2012，Vol.33Issue(6)：596-598,3.
瑞舒伐他汀钙对冠心病患者外周血内皮前体细胞水平的干预作用
Effect of rosuvastatin on endothelial progenitor cells in peripheral blood of patients with coronary heart disease
郭文静 1李晓燕 2张红明 2韩淑芳 2康玲3
作者信息
- 1. 辽宁医学院,济南军区总医院研究生培养基地,济南,250031
- 2. 济南军区总医院,济南,250031
- 3. 泰山医学院附属医院,泰安,271000
- 折叠
摘要
Abstract
Objective To study the lipid-regulating function of rosuvastatin by observing its effect on endothelial prognostic cells (EPC) marked by CD34+ and vascular endothelial growth factor-2+(VEGFR-2+) in peripheral blood of patients with coronary heart disease(CHD). Methods One hundred and twelve patients with CHD diagnosed by percutaneous coronary angiography were divided into single-vessel lesion group(n=37), double-vessel lesion group(n=36) and triple-vessel lesion group(n=39). The patients were treated with 10mg rosuvastatin calcium, once a night. The number of EPC marked with CD34+ and VEGFR-2+ was detected by flow cytometry 1 month before and after treatment. Results The TC and LDL-CH levels were significantly lower 1 month after treatment than before treatment(P<0.001). The TG level was lower after treatment than before treatment(P<0.05), but no significant difference was observed in HDL-CH level(P>0.05). The number of EPC marked with CD34+ and VEGFR-2+ decreased gradually with the aggravation of CHD(P<0.05) and was significantly higher in CHD patients after treatment than before treatment(P<0.05). Conclusion Rosuvastatin can increase the number of EPC in peripheral blood of CHD patients, besides its good lipid-regulating function, thus slowing down the coronary atherosclerotic process.关键词
冠心病/CD34+/VEGFR-2+血管内皮前体细胞/流式细胞术/瑞舒伐他汀钙片Key words
coronary heart disease/ CD34+/VEGFR-2+ endothelial progenitor cells/ flow cytometry/ rosuvastatin calcium tablets分类
医药卫生引用本文复制引用
郭文静,李晓燕,张红明,韩淑芳,康玲..瑞舒伐他汀钙对冠心病患者外周血内皮前体细胞水平的干预作用[J].军医进修学院学报,2012,33(6):596-598,3.
