军医进修学院学报2012，Vol.33Issue(6)：665-667,676,4.
热灼联合液氮冷冻建立兔中晚期股骨头缺血性坏死动物模型
Rabbit intermediate-late avascular necrosis of femoral head model induced by thermal injury in combination with liquid nitrogen freezing
李富强 1宁亚功 2张恩龙 2徐文漭 2李峻辉2
作者信息
- 1. 解放军总医院/军医进修学院,北京,100853
- 2. 成都军区昆明总医院,昆明,650032
- 折叠
摘要
Abstract
Objective To study the rabbit intermediate-late avascular necrosis femoral head(ANFH) model induced by thermal injury in combination with liquid nitrogen freezing. Methods Twenty 5-month old Japanese big-ear rabbits were included in this study. A intermediate-late ANFH model was induced by thermal injury in combination with liquid nitrogen freezing without dislocation of hip joint to observe their gross anatomy 1, 2, 4, 6 and 8 weeks after operation. Tissue sections were observed under optical microscopy and examined by X-ray and MRI. Results Necrosis of femoral head occurred 1 week after operation and was repaired 2 weeks after operation. Joint surface of femoral head was collapsed 4 weeks after operation, which was aggravated 6 weeks after operation and became flat and smaller with osteoarthritis at week 8 after operation. Conclusion Thermal injury in combination with liquid nitrogen freezing can be used to establish rabbit intermediate -late ANFH model with no death of rabbits and a high success rate.关键词
动物模型/股骨头坏死/液氮/冷冻Key words
animal model/ femoral head necrosis/ lquid nitrogen/ freezing分类
医药卫生引用本文复制引用
李富强,宁亚功,张恩龙,徐文漭,李峻辉..热灼联合液氮冷冻建立兔中晚期股骨头缺血性坏死动物模型[J].军医进修学院学报,2012,33(6):665-667,676,4.
