军医进修学院学报2012，Vol.33Issue(6)：668-671,4.
慢性萎缩性胃炎的动物模型研究
Establishment of animal chronic atrophic gastritis model
冯秀雪 1令狐恩强1
作者信息
- 1. 解放军总医院,消化科,北京,100853
- 折叠
摘要
Abstract
Objective To establish an stable experimental model of chronic atrophic gastritis(CAG) in rats and investigate the effect on the liver preliminarily by stimulating rat gastric mucosa with multiple factors. Methods Rats were randomly divided into model group and normal control group. Rat in model group had free access to 0.1% ammonia water and drank a mixture of 2% sodium salicylate and 30% alcohol for the first 10 weeks followed by 20mmol/L sodium deoxycholate for the next 12 weeks, while those in normal group had free access to drinking water for 22 weeks. Results The general condition was worse, the body weight gain was slower, the atrophy of glands was more significant, the mucosa was thinner, the muscular layer of mucosa was thicker, and the infiltration of inflammatory cells was severer in model group than in normal control group. No intestinal metaplasia and dysplasia, and no obvious abnormality of liver pathology were observed in two groups. Conclusion A CAG model is successfully established by stimulating gastric mucosa with multiple factors, with no obvious effect on liver pathology.关键词
慢性萎缩性胃炎/动物模型/大鼠Key words
chronic atrophic gastritis/ animal model/ rats分类
医药卫生引用本文复制引用
冯秀雪,令狐恩强..慢性萎缩性胃炎的动物模型研究[J].军医进修学院学报,2012,33(6):668-671,4.
