军医进修学院学报2012，Vol.33Issue(7)：767-769,3.
黄连解毒汤抑制NF-κB激活减轻心肌缺血再灌注损伤
Antidotal Decoction of Coptis reduces myocardial ischemia/reperfusion injury by inhibiting activation of NF-κB
摘要
Abstract
Objective To study the protective effect of Antidotal Decoction of Coptis(ADC) on myocardial ischemia/reperfusion(I/R) injury and its mechanism. Methods A SD rat myocardial I/R injury model was established. Fifty-six SD male rats were randomly divided into sham operation group, myocardial I/R group, 1% CMC-Na control group, and low dose ADC group, medium dose ADC group, high dose ADC group, and composite red sage root group. The rats were given drugs for successive 7 days. The myocardial I/R injury model was replicated 24h after the last drug administration. SOD activity, MDA level, and myocardial infarct area were measured 40min after reperfusion to judge the protective effect of ADC on myocardium. Myocardial tissue sample was taken to measure the nuclear transcription activity of NF- k B. Results Forty minutes after reperfusion, the SOD activity, MDA level and myocardial infarct area were obviously improved in experimental groups, the nuclear transcription activity of NF- k B was significantly lower in experimental groups than in control group. Conclusion ADC protects rats against myocardial I/R injury by inhibiting the activation of NF- k B.关键词
黄连解毒汤/核转录因子κB/心肌缺血再灌注损伤Key words
huanglian jiedu decoction/ NF- k B/ myocardial ischemia reperfusion injury分类
医药卫生引用本文复制引用
付晓春,陈建军,王舰平..黄连解毒汤抑制NF-κB激活减轻心肌缺血再灌注损伤[J].军医进修学院学报,2012,33(7):767-769,3.基金项目
广东省自然科学基金项目(S2011010001536) （S2011010001536）
