昆明医学院学报2012，Vol.33Issue(3)：1-4,7,5.
TGF-β1和CNTF在大鼠移植神经干细胞后的损伤脊髓中的表达
Expression of TGF-β1 and CNTF in Injuried Spinal Cord after NSCs Transplantation
摘要
Abstract
Objective To study the effect of neural stem cells (NSCs) transplantation on the expression of TGF- betal and CNTF in injured spinal cord. Methods 35 SD Female rats were randomly divided into 3 groups: merely spinal cord transection group, sham operation group and NSCs transplantation group. NSCs transplantation was performed on 7th d after spinal cord transection in NSCs transplantation group, but was not performed in the other two groups. Expression of TGF- β land CNTF in the proximum of the injury spinal cord were detected on 3rd d, 7th d, 14th d after NSCs transplantation by RT- PCR. Results Expression level of TGF-β 1 in merely spinal cord transection group was higher than that in NSCs transplantation group on 3rd d and 7th d. Expression level of CNTF in merely spinal cord transection group was only higher than that in NSCs transplantation group on 7th d. Conclusion NSCs transplantation can downregulate the expression of TGF- β 1, but has no effect on the expression of CNTF in injured spinal cord.关键词
脊髓损伤/TGF-β/CNTFKey words
Spinal cord injury/ TGF- betal/ CNTF分类
医药卫生引用本文复制引用
巴迎春,范艳,王金德,唐少峰,王廷华..TGF-β1和CNTF在大鼠移植神经干细胞后的损伤脊髓中的表达[J].昆明医学院学报,2012,33(3):1-4,7,5.基金项目
云南省自然科学基金资助项目( 2007COO48R) （ 2007COO48R）
