临床与实验病理学杂志2012，Vol.28Issue(6)：623-626,4.
甲状腺乳头状癌中PPM1D的表达和意义
Expression of PPM1D in papillary carcinoma of thyroid and its significance
摘要
Abstract
Purpose To investigate the expression of PPMf D in papillary carcinoma of thyroid ( PTC ) and its relationship with clinico-pathologic features and p53. Methods The expression of PPMf D protein was detected in 55 cases of PTC tissues compared with normal tumor-adjacent thyroid tissues by immunohistochemistry. The data was analyzed statistically to evaluate the relationship between the expression of PPMf D, p53 and the clinicopathologic features. Results The expression of PPMf D was much higher in PTC ( 74. 5% , 41/55 ) than that in normal tumor-adjacent thyroid tissues( 10. 9% , 6/55 ). The difference was statistically significant P < 0. 05 ). PPMf D was found high-expressed in PTC with interstitial cirrhosis ( P <0. 05 ). PPMf D also showed negative correlation with p53( r = -0. 339, P <0. 05 ) in PTC. Conclusions Increased expression of PPMf D is associated with thyroid papillary carcinoma and the potential coordination between PPMf D and p53 may play an important role in the process of tumor genesis and development.关键词
甲状腺肿瘤/乳头状癌/PPM1D/p53/免疫组织化学Key words
thyroid neoplasms/ papillary carcinoma/ PPM1D/ immunohistochemistry分类
医药卫生引用本文复制引用
任伟民,张友元,罗金芳,叶宣光,董军明..甲状腺乳头状癌中PPM1D的表达和意义[J].临床与实验病理学杂志,2012,28(6):623-626,4.基金项目
上海市卫生局面上项目(2010-51) （2010-51）
