南京医科大学学报（自然科学版）2012，Vol.32Issue(3)：374-377,4.
5-Fu减轻急性MODS模型全身性损伤的实验研究
Experimental study of 5-Fu to reduce systemic injury in acute model of MODS
摘要
Abstract
Objective:To observe the effects of a single dose of 5-fluorouracil (5-Fu) on multiple organ functions and the survival time of rats with multiple organ dysfunction syndrome (MODS). Methods: The study adopted the methods of multiple fractures + scald + Pseudomonas aeruginosa infection to produce the model of SD rats with acute MODS. The rats were randomly divided into MODS model group(n = 36) and treatment group(MODS model+5-Fu,n = 26),each being divided into four subgroups. The rats were sacrificed 24,48,72 or 96 h after the models were built successfully,blood samples were collected to examined the leukocyte numbers of peripheral blood,the leukocyte function,liver and kidney function and myocardial enzymes. Rats' mortality rate was observed as well. Results; Compared with MODS model group,5-Fu restrained the leukocyte numbers of peripheral blood in the early and middle stages. 5-Fu had no effect on leukocyte respiratory burst but reduced the CD11b expression. During the experiment,rats' mortality rate of 5-Fu treatment group decreased significantly. There were no differences in serum activity of alanine aminotransferase,aspartate aminotransferase,creatine kinase,creatine kinase isoenzyme,and no differences in blood urea nitrogen between the two groups. The blood glucose level were improved at different stages of 5-Fu group,but increased progressively in contrast group. Conclusion; A single administration of 5-Fu may protect rats with MODS against systemic injury.关键词
5-氟尿嘧啶/多器官功能障碍综合征/大鼠Key words
5-fluorouracil/multiple organ dysfunction syndrome/rats分类
医药卫生引用本文复制引用
卞建民,江强,章世海..5-Fu减轻急性MODS模型全身性损伤的实验研究[J].南京医科大学学报（自然科学版）,2012,32(3):374-377,4.基金项目
南京市医学科技发展项目(YKK08085) （YKK08085）
