南京医科大学学报（自然科学版）2012，Vol.32Issue(3)：378-381,4.
高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究
The change of plasma adiponectin level and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage
摘要
Abstract
Objective:To detect the change of plasma adiponectin and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage. Methods: Blood samples of 30 cases in control group and 43 patients with hypertensive cerebral hemorrhage were obtained 1,2,3,5,and 7 days after hospitalization. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay were used to measured concentrations of plasma adiponectin,interleukin-6 (I1-6),C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α). Results: After hypertensive cerebral hemorrhage,the level of plasma adiponectin increased immediately within 6 h, reached the peak at 24 h,and decreased gradually after 2 days. The adiponectin concentration was higher in patients with hypertensive cerebral hemorrhage than control group during 7 days. The levels of plasma IL-6,CRP,and TNF-a in patients with hypertensive cerebral hemorrhage were significantly higher than those in control group,and were associated with adiponectin level. Conclusion: The change of plasma adiponectin was a dynamic process. Together with IL-6,CRP,and TNF-α,plasma adiponectin may be involved in the inflammatory responses injury after cerebral hemorrhage.关键词
血浆脂联素/高血压脑出血/高敏C-反应蛋白/白介素-6/肿瘤坏死因子-αKey words
plasma adiponectin/hypertensive cerebral hemorrhage/C-reactive protein(CRP)/interleukin-6(IL-6)/tumor necrosis factor-α(TNF-α)分类
医药卫生引用本文复制引用
王宏,王文宏,游洋,苏正..高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究[J].南京医科大学学报（自然科学版）,2012,32(3):378-381,4.基金项目
江苏省自然科学基金资助(BK2010419) （BK2010419）
