南京医科大学学报（自然科学版）2012，Vol.32Issue(3)：403-407,5.
血尿酸水平与代谢综合征及其各组分的相关性研究
Association of serum uric acid level with metabolic syndrome and its components
摘要
Abstract
Objectlve:To analyze the association of serum uric acid (SUA) level with prevalence and the risk of metabolic syndrome (MS) and its components. Methods: A random,multi-stage cross-sectional study was conducted among adults (18~74 years old) in a rural population in Gaoyou,Jiangsu Province. Blood samples were collected for testing blood glucose,lipid profile and SUA and the relationship between SUA and MS was analysed. A total of 4 493 subjects (2 101 men,2 392 women) are enrolled in our study. Results: ①The mean uric acid level was significantly lower in women than men[(338.41 ± 87.99) vs. (255.01 ± 75.08)μmol/L, P < 0.01]. Prevalence of MS was elevated with the increasing SUA level. ② SUA level increased significantly with the increaseing number of MS components for both gender. Under a low SUA level,women had higher incidence of MS compared with men. ③ After adjustment of age,smoking status,alcohol consumption and estimated glomerular filtration rate(eGFR),SUA was positively correlated with waist,blood pressure,fasting serum glucose and total triglyceride(TG),and inversely correlated with high density lipoprotein cholesterol (HDL-C) while waist and TG had stronger correlation with SUA than other MS components. ④ Logistic analysis showed that SUA was an independent predictor on the risk factor for incidence of MS and its components. The OR (95%CI) value of hyper-glycemia for women was higher in all the four quartiles of SUA levels than men. Conclusion: There is a significant association between serum uric acid level and metabolic syndrome,as well as its components. The risk of hyperglycemia predicted by serum uric acid levels is greater in women than men.关键词
血尿酸/代谢综合征/空腹血糖/甘油三酯Key words
serum uric acid/metabolic syndrome/fasting serum glucose/total triglyceride分类
医药卫生引用本文复制引用
丁扬,马向华,田婷,倪娟,谢媛,杨涛,龚磊,沈捷..血尿酸水平与代谢综合征及其各组分的相关性研究[J].南京医科大学学报（自然科学版）,2012,32(3):403-407,5.基金项目
“十一五”国家科技支撑计划(2008BAI65B09,2007BAI07A10) （2008BAI65B09,2007BAI07A10）
江苏省亚健康高危人群综合干预示范研究项目(BE2009613) （BE2009613）
