南京医科大学学报（自然科学版）2012，Vol.32Issue(3)：424-427,4.
(S)-2,4,6-三甲基苯丙氨酸的立体选择性合成
Synthesis of (S)-2,4,6-trimethylphenylalanine
摘要
Abstract
Objective: Stereoselective synthesis of (S)-2,4,6-trimethylphenylalanine. Methods: 2,4,6-trimethylbenzoic acid was reduced to produce 2,4,6-trimethylbenzyl alcohol (1),which was brominated to generate 2,4,6-trimethylbenzyl bromide (2). The bromide (2) coupled with (S)-BPB-Ni(II)-Gly complex (3) to give (S)-Tmp-Ni(II) complex (4),which was then decomposed by acid to obtain (S)-2,4,6-trimethylphenylalanine (5). Results: (S)-2,4,6-trimethylphenylalanine was successfully synthesized at a total yield of 52.8%. Conclusion: Inexpensive and readily available starting material and reagents,simplicity of the experimental procedure and high yield make this method synthetically attractive for preparing the target amino acid.关键词
(S)-2,4,6-三甲基苯丙氨酸/立体选择性合成/阿片肽Key words
( S ) -2,4,6-trimethylphenylalanine/ stereoselective synthesis/opioid分类
医药卫生引用本文复制引用
李晓闻,郁蕾蕾,刘金春,陈佳佳,常磊,厉廷有..(S)-2,4,6-三甲基苯丙氨酸的立体选择性合成[J].南京医科大学学报（自然科学版）,2012,32(3):424-427,4.基金项目
江苏省高校自然科学基础研究项目(08EJB-350002) （08EJB-350002）
南京医科大学科技发展基金重点项目(08NMUZ-011) （08NMUZ-011）
