南京医科大学学报（自然科学版）2012，Vol.32Issue(3)：428-430,3.
2-[(1H-苯并[d][1,2,3]三氮唑-5-胺基)甲基]-4,6-二氯苯酚的合成
Synthesis of 2- [( 1 H-benzo [d] [1,2,3] triazol-5-ylamino) methyl]-4,6-dichlorophenol
摘要
Abstract
Objective;To synthesize the uncoupler 2-[(1H-benzo [d] [1,2,3]triazol-5-ylamino) methyl]-4,6-dichlorophenol for neuronal nitric oxide synthase(nNOS) with postsynaptic density protein-95(PSD-95). Methods; 5-amine-1H-benzo[d][1,2,3]triazol was firstly synthesized from 4-nitrobenzene-1 ,2-diamine by diazotization and reduction. Then the target compound was obtained by reduction after condensation of 5-amine-1H-benzo[d] [1,2,3]triazol and 3,5-dichloro-2-hydroxybenzaldehyde. Rusults: The target compound was confirmed by hydrogen nuclear magnetic resonance spectra (1H-NMR) and carbon nuclear magnetic resonance spectra (13C-NMR),and the overall yield is 20.3%. Conclusion; The program of experiments can be used to synthesize 2-[(1H-benzo[d] [1,2,3]triazol-5-ylamino) methyl]-4,6-dichlorophenol quickly and easily.关键词
5-氨基-1H-苯并[d][1,2,3]三氮唑/nNOS-PSD-95解偶联剂/合成Key words
1H-benzo[d][1,2,3]triazol-5-amine/nNOS-PSD-95 uncoupler/synthesis分类
医药卫生引用本文复制引用
王凤亮,马腾,许贯虹,张宏娟,王秀珍,李飞..2-[(1H-苯并[d][1,2,3]三氮唑-5-胺基)甲基]-4,6-二氯苯酚的合成[J].南京医科大学学报（自然科学版）,2012,32(3):428-430,3.基金项目
国家自然科学基金(21172108) （21172108）
江苏省自然科学基金(BK2011772) （BK2011772）
