青岛大学医学院学报2012，Vol.48Issue(1)：71-73,3.
GRAVES病药物治疗停药后早期复发相关临床因素分析
EARLY RELAPSE OF GRAVES DISEASE AFTER DISCONTINUATION OF ANTITHYROID DRUG TREATMENT: AN ANALYSIS OF ITS RELATED FACTORS
马利丹 1阎胜利 1李鹏 1王颜刚 1余霄龙 1王娈1
作者信息
- 1. 青岛大学医学院附属医院内分泌与代谢病科,山东青岛266003
- 折叠
摘要
Abstract
Objective To investigate factors associated with an early relapse of GRAVES' disease <GD) after antithy-roid-drug withdrawal. Methods A retrospective analysis was conducted in 118 GD-recurrent patients treated in our hospital from 2008 to 2009, who were divided into early-relapse group (84 cases) and late-relapse group (34 cases) based on whether the recurrence occurred within three years after withdrawal of antithyroid drugs. A comparison was done between the two groups in terms of the following items: age, sex, degree of thyromegaly, exophthalmos, family history, past history of relapse, course of drug treatment, and whether or nor L-T4 and urine iodine were used. Results The early-relapse group versus the late-relapse group, the findings were as follows: in the former, the mean age was much younger (t= 3. 290,P<0. 01); the ratio of thyroid gland remained swelling was higher (x2 = 4. 405,P<0. 05); the treatment course was much longer (t= 4. 213,P<0. 01) ;and the rate of a positive past history of relapse was much higher (x2 =4. 594,P<0. 05), but the differences were not statistically significant between the two groups, in terms of gender, exophthalmos, family history, and whether or not using drug L-T4 and urine iodine (P>0. 05). Conclusion The age, the swelling of thyroid gland, and the past history of relapse are associated with the early relapse of GD.关键词
甲状腺功能亢进症/复发/流行病学因素Key words
hyperthyroidism/recurrence/ epidemiologic factors分类
临床医学引用本文复制引用
马利丹,阎胜利,李鹏,王颜刚,余霄龙,王娈..GRAVES病药物治疗停药后早期复发相关临床因素分析[J].青岛大学医学院学报,2012,48(1):71-73,3.
