四川医学2012，Vol.33Issue(3)：454-457,4.
体外循环心脏直视手术期间天麻素对患者脑血流量/脑氧耗比值的影响
Effect of gastrodin on CBF/CMRO2 in patients undergoing open-heart surgery with cardiopulmonary bypass
汤和青 1林雷 1侯俊 1方为 1陈春 1柯齐斌1
作者信息
- 1. 宜昌市中心人民医院麻醉科,湖北宜昌443003
- 折叠
摘要
Abstract
Objective To observe the effect of Gastrodin on CBF/CMRO2 in patients undergoing open-heart surgery with cardiopulmonary bypass(CPB). To discuss the effect and the mechanism of Gastrodin on cerebral injury undergoing CPB. Methods 30 patients ( ASA physical status II to M ) undergoing replacement of mitral valve were randomly divided into control group ( n = 15 ) and experimental group ( n = 15 ). The gastrodin ( 600mg) was administered in the same time that patient was undergoing routine anaesthesia in experimental group. Saline was administered in the control group. Blood was collected from radial artery and jugular bulb venous for blood gas analysis and blood lactic acid, measure and calculate the jugular bulb oxygen saturation( Sj-vO 2) , arterial oxygen content ( CaO 2) , cerebral oxygen extraction rate ( CERO 2 ) before CPB ( Tl ) , the nose temperature drop to constant temperature regularly to 28 °C ( T2), and 20 minute after heart beating ( T3 ). Results Two groups all stepped up at T2 compared with Tl .stepped down at T3 compared with T2. By group comparison, CBF/ CMRO2 of experimental group was significantly higher than that of another group at T2(P <0.05). Conclusion Undergoing CPB,Gastrodin could reduce cerebral oxygen consumption, would help to improve brain oxygen supply and demand balance, improve cerebral oxygen metabolism, reduce brain lactate production.关键词
天麻素/体外循环/脑血流量/脑氧耗比值Key words
gastrodin/ cardiopulmonary bypass/ CBF/ CMRO 2分类
医药卫生引用本文复制引用
汤和青,林雷,侯俊,方为,陈春,柯齐斌..体外循环心脏直视手术期间天麻素对患者脑血流量/脑氧耗比值的影响[J].四川医学,2012,33(3):454-457,4.
