四川医学2012，Vol.33Issue(4)：618-620,3.
伏立康唑治疗血液病并发侵袭性真菌感染疗效分析
Efficacy of vociconazole in treating invasive fungal infection in patients with blood diseases.
袁凯锋 1唐君灵 1景莉 1周玉萍 1韩丽英1
作者信息
- 1. 泸州医学院附属医院血液科,四川泸州646000
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of voriconazole and ways to reduce health care costs in treating the invasive fugal infection. Methods Retrospective analysis of 43 cases of blood diseases combined invasive fungal infections, according to the different anti-fungal treatment program was divided into two groups. The group one was given intravenous voriconazole treatment, the first day loading dose (0. 4g once per 12 hour) , and then a maintenance dose (0. 2g once per 12 hour) ; After the body temperature become normal and last one or two weeks, the oral voriconazole tablets was given at 0. 2g once per 12 hour for maintenance therapy. The group two was given oral voriconazole tablets, the first day loading dose (0. 4g once per 12 hour) , and then a maintenance dose (0. 2g once per 12 hour). Results There were four patients getting a transient elevated transaminases, two patients getting visual disturbances and two patients getting skin rashes. There were not occurrence of arrhythmia, kidney damage, edema and other adverse reactions. The efficiency of anti-fungal in group one was 79. 2% , and 63. 2% in group two; the cure rate of anti-fungal in group one was 54. 2% , and 42. 1 % in group two, there was not a significant difference between the two groups(P>0. 20). Conclusion Voriconazole to treat invasive fungal infections was safe and effective. First select oral formulation of voriconazole to treat invasive fungal infections was expected to become effective, low cost and the recommended method.关键词
伏立康唑/血液病/侵袭性真茵感染Key words
voriconazole/ blood diseases/ invasive fungal infection分类
医药卫生引用本文复制引用
袁凯锋,唐君灵,景莉,周玉萍,韩丽英..伏立康唑治疗血液病并发侵袭性真菌感染疗效分析[J].四川医学,2012,33(4):618-620,3.
