肿瘤预防与治疗2012，Vol.25Issue(3)：164-167,4.DOI:10.3969/j.issn.1674-0904.2012.03.008
调强适形放疗同步吉西他滨治疗36例局部晚期胰腺癌的临床观察
Clinical Observation of Gemcitabine Combined with Intensity Modulated Radiation Therapy for 36 Cases of Locally Advanced Pancreatic Cancer
颜高姝 1彭瑛 1罗阳坤 1樊伶俐 1文浩 1王捷1
作者信息
摘要
Abstract
Objective; To explore the curative effect and toxic reaction of Gemcitabine combined with intensity modulated radiation therapy(IMRT) for locally advanced pancreatic cancer. Methods; Thirty-six patients were treated by IMRT ( GTV D95 2Gy/f, total dose; 66Gy ~70Gy ) combined with Gemcitabine (1 000mg/m2 , intravenously, dl,d8, 28 days as one cycle, total 4 - 6 cycles) . Results; All patients finished the concurrent chemoradiotherapy. The total response rate was 88. 9% and the local control rate was 91. 6% . The medium survival time was 18. 6 months, and the 1-and 2-year survival rate was 60. 8% , 22. 1% respectivly. The pain-alleviation rate was 94% (34/36) . Life quality of patients improved obviously. ECOG score was improved in 19(52.8%) cases. Conclusion; Gemcitabine combined with IMRT is effective and well-tolerated for the treatment of locallyadvanced pancreatic cancinoma.关键词
晚期胰腺癌/放疗/吉西他滨/疗效Key words
Advanced Pancreatic Cancer/ Radiotherapy/ Gemcitabine/ Curative Effect分类
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颜高姝,彭瑛,罗阳坤,樊伶俐,文浩,王捷..调强适形放疗同步吉西他滨治疗36例局部晚期胰腺癌的临床观察[J].肿瘤预防与治疗,2012,25(3):164-167,4.
