四川中医2012，Vol.30Issue(4)：17-19,3.
丹龙定喘汤对哮喘小鼠气道重塑及血清TGF-β1的影响研究
Effects of Danlong Dingchuan Decoction on Expression of TGF-β1 and Airway Remodeling in Asthmatic Mice
田金娜 1李建保 1刘小凡1
作者信息
- 1. 成都中医药大学附属医院儿科,四川成都610072
- 折叠
摘要
Abstract
Objective; Exploring the effect of Danlong Dingchuan Decoction (DDD) on expressions of TGF-β1 and airway remodeling in asthmatic mice. Methods; 56 SPF Balb/c mice were randomly divided into normal group, model group, western medicine group, DDD group. The three groups were established asthmatic model in mice allergized with OVA except normal group. At the 41 ~69days in the experiment, the normal and model group were treated with normal saline. Meanwhile, the western medicine group, DDD group were respectively given Dexamethasone and DDD. At the end of experiment, we observed the pathomorphological change in lung issues and took the sample blood to detect TGF-β1 with the way of ELLSA. Results; The pathological changes in lung tissue showed that DDD could significantly reduce the infiltration of inflammatory cells and inhibited bronchial smooth muscle thickened. The level of TGF-pi of model group was significantly increased compared with the normal group (P<0. 01). In western medicine group and DDD group, the content of TGF-βl were significantly decreased (P<0. 01), and there was no significant difference between the two groups (P>0.05). Conclusion; DDD can decrease the content of TGF-(31 and suppress airway remodeling in asthmatic mice.关键词
丹龙定喘汤/哮喘/气道重塑/转化生长因子β1Key words
Danlong Dingchuan/ Decoction/ Asthma /Remodeling TGF-β1分类
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田金娜,李建保,刘小凡..丹龙定喘汤对哮喘小鼠气道重塑及血清TGF-β1的影响研究[J].四川中医,2012,30(4):17-19,3.
