山东医药2012，Vol.52Issue(9)：61-63,3.
类风湿关节炎患者骨密度及骨矿物质含量的变化及意义
Changes of bone mineral density and bone mineral conten in patients with rheumatoid arthritis and its significance
摘要
Abstract
Objective To investigate the changes and clinical significance between bone mineral density ( BMU; and bone mineral con ten (BMC) in patients with rheumatoid arthritis ( RA). Methods The BMD and BMC of patients of RA and normal control group were measured by means of dual energy X-ray absorptiometry in the forearm. The correlations of indexes were analyzed by linear correlation analysis and multiple linear regression analysis. Results The BMD and the BMC of patients with RA were significant deceased compared to normal control group (P < 0.05 ). The BMD in forearm was negatively correlated with DAS28 score, ESR and RF (r= -0.357, -0.390, -0.255, P<0.05) , respectively. There was a significant negative correlation between BMC in forearm and DAS28 score, ESR ( r = - 0. 344, -0.401, P< 0.05). And multiple linear regression analysis showed that the BMD in forearm with RF and age were negatively correla-ted ; The BMC in forearm was negatively correlated with the DAS score. The patients of RA with X-ray for the period I have 15 cases, which 6 patients showed osteoporosis, bone mass decreased by 2 cases, bone loss and osteoporosis in patients with a total of 8 cases. Conclusions The declines of BMD and BMC of patients with RA are more obvious; BMD and BMC loss may be closely related with disease activity; The BMD may be reflected the loss of bone mass in patients with RA more reflected earlier than X-ray.关键词
类风湿关节炎/骨密度/骨矿盐Key words
rheumatoid arthritis/ bone mineral density/ bone mineral conten分类
医药卫生引用本文复制引用
吕伟,厉小梅,马艳,俞大亮,陈超,李向培,汪国生,钱龙..类风湿关节炎患者骨密度及骨矿物质含量的变化及意义[J].山东医药,2012,52(9):61-63,3.基金项目
安徽省高层次人才创新创业资金资助项目(090413129). （090413129）
