山东医药2012，Vol.52Issue(12)：14-16,3.
大剂量雌激素对中重度宫腔粘连预后的影响
Effect of high dose estrogen in prognosis of moderate or serious intrauterine adhesion
摘要
Abstract
Objective To investigate the effect of high dose estrogen in prognosis of moderate or serious intrauterine adhesion (IUA) and correlation between estrogen receptor with prognosis. Methods Sixty patients with serious or moder-ate IUA underwent hysteroscopic adhesiolysis. They were randomly divided into two groups, the study group; applying Es-tradiol valerate (progynova) 10 mg per os quaque die for 3 months; the control group: Estradiol valerate 10 mg per os quaque die for 21 days, provera 8 mg per os quaque die with the last 10 days as one period, and taking three periods. All patients came back to the hospital for hysteroscopy in one month and three months post operation. Results Follow-up peri-od was 6 to 12 months. The effective power was 88.3% (53/60) for all patients who uterine cavity recovered normal in 3 months postoperatively, the study group was 90% ( healing rate 46.7% , improvement rate 43.3% ) , the control group was 86.7% ( healing rate 46.7% , improvement rate 40% ) respectively ( P > 0.05 ). The effective power was 76. 7% ( 46/ 60) for all patients who menstrual returned to normal in 6 months postoperatively, the study group was 90% ( healing rate 46. 7% , improvement rate 43.3% ) , the control group was 63.3% (healing rate 23.3% , improvement rate 40% ) respec-tively (P < 0.05 ). The result of hysteroscopy post operation had positive correlation with ER positive express rate ( r = 0. 339, P < 0.01). Ten patients had gesration, pregnancy rate was 41.7% (10/24). Conclusions Patients with serious or moderate IUA treated with high dose Estradiol Valerate could reduce re-adhesion effectively, admitting had advantage continuously than periodically. As the expression of ER increasing, the prognosis of IUA got improved markedly.关键词
宫腔粘连/戊酸雌二醇/雌激素受体/预后Key words
intrauterine adhesion/ asteroidal valerate/ estrogen receptor/ prognosis分类
医药卫生引用本文复制引用
刘玉环,赵玉婷,蒋东桥,夏恩兰,刘琳琳,宋冬梅,郑杰,彭雪冰..大剂量雌激素对中重度宫腔粘连预后的影响[J].山东医药,2012,52(12):14-16,3.基金项目
首都医科大学基础-临床科研合作基金资助项目(2009JL1008). （2009JL1008）
