山东医药2012，Vol.52Issue(12)：48-50,56,4.
两种剂量他汀对冠脉粥样硬化斑块的作用及其疗效和安全性
Effects of intensive treatment of statin towards atherosclerosis plaques in patients with borderline vulnerable plaque lesion
摘要
Abstract
Objective To compare the efficacy and safety of atorvastatin intensive treatment towards borderline vulner-able plaque lesion in unstable angina pectoris ( UAP) patients by intravascular ultrasound. Methods A total of 100 pa-tients undergoing coronary angiography (CAG) with borderline lesion ( coronary artery stenosis between 50% - 70% ) , who were divided into two groups, the intensive treatment group and the common treatment group. One 50% ~ 70% stenosis plaque was selected as target plaque in each patient. Coronary artery angiography ( CAG) and target plaque intravascular ultrasound (IVUS) were performed on admission. Nine months later, to compare the plaque volume, lumen volume and vascular volume. Results Nine months later, in common treatment group plaque volume increased ( P < 0. 05), but all the indexes showed no significantly changes in intensify statins group ( P > 0. 05 ). Conclusion Atorvastatin intensive therapy can prevent the development of atherosclerotic plaque of UAP patients.关键词
不稳定心绞痛/粥样硬化斑块/阿托伐他汀/血管内超声Key words
unstable angina pectoris/ atherosclerotic plaque/ atorvastatin/ intravascular ultrasound分类
医药卫生引用本文复制引用
张鑫,杜润,刘珊珊,王海容,邱建平..两种剂量他汀对冠脉粥样硬化斑块的作用及其疗效和安全性[J].山东医药,2012,52(12):48-50,56,4.基金项目
上海市浦东新区重点学科建设基金(PWZxk2010-05) （PWZxk2010-05）
上海浦东新区学科带头人培养基金(PWRd2011-04). （PWRd2011-04）
