山东医药2012，Vol.52Issue(12)：51-53,3.
ERK-1/2对N/OFQ调节大鼠皮层神经元延迟整流钾电流激活动力学的影响
Effects of ERK-1/2 on the modulation of delayed rectifier potassium current activation kinesics by N/OFQ in acutely dissociated rat cerebral parietal cortical neurons
摘要
Abstract
Objective To investigate the effects of ERK-1/2 on modulation of delayed rectifier potassium current (IK) activation kinesics by N/OFQ in acutely dissociated rat cerebral parietal cortical neurons. Method Whole-cell volt-age clamp technique was used. Result In presence of U0126, inhibitor of ERK-1/2, 0. 1 μmol/L N/OFQ shifted the ac-tivation curve of IK to hyperpolarize potential from ( -42 ± 3.7) mV to ( -39.9 ± 5.9) mV (P<0.01) and changed the slope factor ( κ) of the activation curve from (21.6 ± 8.1) mV to (22. 9 ± 3. 8) mV (P <0.05). Conclusion These data sustained our contention that U0126 inhibited the positive shift of IK activation induced by N/OFQ.关键词
ERK-1/2/延迟整流钾电流/全细胞膜片钳技术/孤啡肽/大鼠Key words
ERK-1/2/ delayed rectifier potassium current/ whole-cell voltage clamp technique/ orphanin FQ/noei-ceptin/ rat分类
医药卫生引用本文复制引用
李晓红,王艳丽,张宇,刘程伟,曲丽辉..ERK-1/2对N/OFQ调节大鼠皮层神经元延迟整流钾电流激活动力学的影响[J].山东医药,2012,52(12):51-53,3.基金项目
国家自然科学基金-青年科学基金项目(30900489) （30900489）
国家自然科学基金资助项目(30801123). （30801123）
