山东医药2012，Vol.52Issue(20)：19-21,24,4.
复方苦豆子对肾性高血压复合高脂血症大鼠血浆内皮素和一氧化氮合成酶的影响
Effects of Compound KuDouZi on endothelin and nitric oxide synthase in plasma in renal hypertension combined hyperlipidemia rats
摘要
Abstract
Objective To study the effects of Compound KuDouzi (CK) en blood pressure, body weight, liver lip-ids, plasuna endouielin (ET) , muic oxide synthase in renal hypertension combined hypertipidemia rats. Methods To establish two kidney one clip (2K1C) renal hypertension rat compound hyperlipidemia model. The successful model of rats were randomly divided into 5 groups and given different interventions for 8 weeks; the model group; CK high, medium and low Jose group; positive control group. Another 10 raw for the sham gmup. Observed the rats body weight changes at 0 week, 1 week, 2 weels, 4 weeks, 8 weeks. When the experience were over, systolic blood pressure, heart rate and plasma ET, total nitric oxide synthase and nitric oxide synthase (T-NOS and cNOS) , liver hpid (TC, TG) were measured. Results After 2 weeks, the rats body weight decreased and the state was poor, weight of the drug-treated rats increased compared with model group, after 4 weeks of treatment incteased significantly (P <0.05). When the enpenetice were over, in middle-dose and high-dase group blood pressure decreased significantly (P < 0.01) , the plasma levels of ET reduced (P< 0.01), NOS levels increased (P <0.01) , and liver homogenate TC, TG content were lower (P <0.01). Conclusion CK can reduce blood pressure and regulate blood Jipids in high blood pressure compound hyperlipidemia rats, the niecha-nism of CK may be related to endoShelial system conditioning.关键词
复方苦豆子/高血压复合高脂血症/血压/血脂/内皮素/一氧化氮合成酶Key words
Dompound KuDouZi/ renal hypertension combined hyperlipidemia/ Wood pressure/ blood lipida/ endothelin/ nitric oxide synthase分类
医药卫生引用本文复制引用
刘晓敏,陈虹..复方苦豆子对肾性高血压复合高脂血症大鼠血浆内皮素和一氧化氮合成酶的影响[J].山东医药,2012,52(20):19-21,24,4.基金项目
新疆生产建设兵团医药专项(04GC24). （04GC24）
